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U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

Improving the understanding, detection, and management of kidney disease.

Meeting Minutes – Laboratory Working Group Meeting
July 30, 2008

National Institute Of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Kidney Disease Education Program (NKDEP) Laboratory Working Group Meeting
AAAC Annual Meeting – Washington, DC

Participants: Greg Miller (Chair),George Schwartz, Leigh Ann Milburn, Mauro Panteghini, Chandra Jain, Neil Greenberg, David Lacher, John Lieske, Glen Hortin, Graham Jones, Joris Delanghe, Eileen Newman, David Seccombe, Karen Phinney, Matthew McQueen, David Bunk, Mary Robinson, John Eckfeldt, Yoshihisa Itoh, Andrew Narva, David Bruns, Gary Myers, Nancy Xu, Nancy Accetta, Christen Horn

Summary of Action Items:

Meeting Minutes

1. Urine Albumin Group Activities, Greg Miller, Working Group Chair

Background: In 2007 there was a conference in collaboration with the IFCC on current issues and reporting of urinary albumin excretion. A manuscript on that conference has been submitted and favorably reviewed by Clinical Chemistry; once the manuscript has final acceptance, a draft will be circulated to those in the group that were not part of the albumin conference. Also in 2008, the IFCC's and NKDEP's working groups on albumin standardization merged with Greg Miller as the Chair of this joint committee. Membership in this joint working group will be comprised of those who take active roles on the urine albumin projects identified at this meeting.

Urine Working Group Conference Recommendations:

Additional clarification needed in order to make final recommendations and build a reference system:

Subsequent steps that require the above clarifications and standardization components to be in place:

2. Biologic variability, adsorption to containers, and frozen stability of urine albumin, Mary Robinson, Centers for Disease Control and Prevention

Evaluation of intra-individual biologic variation of urinary albumin is funded by the National Center for Chronic Disease Prevention and Health Promotion at CDC. Gary Myers and Mary Robinson are the lead investigators from CDC who wrote the proposal; additional project members are Greg Miller, James Richie, David Koch.

Part 1: Assess adsorption, storage, and freeze-thaw cycles:

Part 2: Assess biological variability in three ethnic groups:

Comments from LWG members:

3. Other Issues

Molecular forms of albumin, Glen Hortin NIH Clinical Center

Understanding the matrix of urine:

4. Update: Status of Pediatric Equations, George Schwartz, University of Rochester

5. Update: Status of Working Group to Address Pharmacy Issues, Andrew Narva, Director, NKDEP National Institute of Diabetes and Digestive and Kidney Diseases

6. Introduction of Revised Website (Lab Professionals Section), Nancy Accetta, NKDEP

No report was made due to lack of time; Nancy Accetta will send an e-mail with information

7. Next Steps, Greg Miller

Meeting adjourned at 2:45 pm

Page last updated: March 1, 2012